FDA Alert - Drug Safety Communication: Methylene Blue - Serious CNS Reactions Possible When Given to Patients Taking Certain Psychiatric Medications

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Alert FDA MedWatch Alert
Sent to subscribers of: methylene blue systemic
July 26, 2011
Audience: Emergency Medicine, Critical Care Medicine, Psychiatry.
ISSUE: FDA has received reports of serious central nervous system (CNS) reactions when the drug methylene blue is given to patients taking psychiatric medications that work through the serotonin system of the brain (serotonergic psychiatric medications). A list of the serotonergic psychiatric medications that can interact with methylene blue can be found in the Drug Safety Communication. Safety information about this potential drug interaction and important drug usage recommendations for emergency and non-emergency situations are being added to the drug labels for serotonergic psychiatric medications.
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